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The dose was divided into two doses with a taper period in which just half of the target dose was given for the first 2 weeks

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Settlean analytical version of the Shake and Rattle algorithm for rigid water models

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Dulaglutide may be taken with or without food

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Another strategy to increase GLP-1's biological half-life is to incorporate a DPP-4 resistant GLP-1 analog into a polymer or other container enabling sustained release

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